Rebalancing the Levels of Ccl17 and Ccl22 to Improve Rheumatoid Arthritis

Screening of the FDA-approved drug library identifies CCL17 inhibitors that block arthritic pain

M Eivazitork, TJ Lupancu, K Lim, YK Huang, JA Hamilton, KMC Lee, AA Achuthan

2025-12-01

Rheumatoid arthritis (RA) is an inflammatory and destructive autoimmune polyarthritis that causes pain, swelling and deformity in ..

Transforming growth factor-β in tumor microenvironment: Understanding its impact on monocytes and macrophages for its targeting

T Hourani, A Sharma, RB Luwor, AA Achuthan

2025-01-01

TGF-β is a pivotal cytokine that orchestrates various aspects of cancer progression, including tumor growth, metastasis, and immun..

Epigenetic and transcriptional regulation of cytokine production by Plasmodium falciparum-exposed monocytes

David VL Romero, Thivya Balendran, Wina Hasang, Stephen J Rogerson, Elizabeth H Aitken, Adrian A Achuthan, Adrian A Achuthan

2024-02-05

Plasmodium falciparum infection causes the most severe form of malaria, where excessive production of proinflammatory cytokines ca..

Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes

T Hourani, M Eivazitork, T Balendran, K MC. Lee, JA Hamilton, HJ Zhu, J Iaria, AP Morokoff, RB Luwor, AA Achuthan

2024-02-01

Transforming growth factor-β (TGF-β) is a pleiotropic cytokine essential for multiple biological processes, including the regulati..

Label-free macrophage phenotype classification using machine learning methods

T Hourani, A Perez-Gonzalez, K Khoshmanesh, R Luwor, AA Achuthan, S Baratchi, NM O’Brien-Simpson, A Al-Hourani

2023-12-01

Macrophages are heterogeneous innate immune cells that are functionally shaped by their surrounding microenvironment. Diverse macr..

Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritis

TJ Lupancu, KMC Lee, M Eivazitork, C Hor, AJ Fleetwood, AD Cook, M Olshansky, SJ Turner, R de Steiger, K Lim, JA Hamilton, AA Achuthan

2023-10-20

Glucocorticoids (GCs) are potent anti-inflammatory agents and are broadly used in treating rheumatoid arthritis (RA) patients, alb..

Targeting transcription factors for therapeutic benefit in rheumatoid arthritis

T Balendran, K Lim, JA Hamilton, AA Achuthan

2023-01-01

Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes pain and disability. Many of the currently ..

Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization

K Ming-Chin Lee, AA Achuthan, DP De Souza, TJ Lupancu, KJ Binger, MKS Lee, Y Xu, MJ McConville, NA de Weerd, D Dragoljevic, PJ Hertzog, AJ Murphy, JA Hamilton, AJ Fleetwood

2022-04-19

Metabolic adaptations can directly influence the scope and scale of macrophage activation and polarization. Here we explore the im..

Targeting GM-CSF in inflammatory and autoimmune disorders

AA Achuthan, KMC Lee, JA Hamilton

2021-04-01

Granulocyte macrophage-colony stimulating factor (GM-CSF) was originally identified as a growth factor for its ability to promote ..

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

DP De Souza, A Achuthan, MKS Lee, KJ Binger, MC Lee, S Davidson, DL Tull, MJ McConville, AD Cook, AJ Murphy, JA Hamilton, AJ Fleetwood

2019-10-01

Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle inter..